Publications

2024

Gurkan UA, Wood DK, Carranza D, Herbertson LH, Diamond SL, Du E, Guha S, Di Paola J, Hines PC, Papautsky I, Shevkoplyas SS, Sniadecki NJ, Pamula VK, Sundd P, Rizwan A, Qasba P, Lam WA. Next generation microfluidics: fulfilling the promise of lab-on-a-chip technologies. Lab Chip. 2024. Epub 20240315. doi: 10.1039/d3lc00796k. PubMed PMID: 38487919.

2023

Williams DC, Wood DK. High-throughput quantification of red blood cell deformability and oxygen saturation to probe mechanisms of sickle cell disease. Proc Natl Acad Sci U S A. 2023;120(48):e2313755120. Epub 20231120. doi: 10.1073/pnas.2313755120. PubMed PMID: 37983504; PMCID: PMC10691249.

Wang J, Calizo A, Zhang L, Pino JC, Lyu Y, Pollard K, Zhang X, Larsson AT, Conniff E, Llosa NJ, Wood DK, Largaespada DA, Moody SE, Gosline SJ, Hirbe AC, Pratilas CA. CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon RB function in malignant peripheral nerve sheath tumors. Sci Adv. 2023;9(47):eadg8876. Epub 20231124. doi: 10.1126/sciadv.adg8876. PubMed PMID: 38000020; PMCID: PMC10672174.

Parmar S, Gonzalez SJ, Heckel JM, Mukherjee S, McClellan M, Clarke DJ, Johansson M, Tank D, Geisness A, Wood DK. Robust microtubule dynamics facilitate low-tension kinetochore detachment in metaphase. Journal of Cell Biology. 2023;222(8):e202202085.

Larsson AT, Bhatia H, Calizo A, Pollard K, Zhang X, Conniff E, Tibbitts JF, Rono E, Cummins K, Osum SH, Williams KB, Crampton AL, Jubenville T, Schefer D, Yang K, Lyu Y, Pino JC, Bade J, Gross JM, Lisok A, Dehner CA, Chrisinger JSA, He K, Gosline SJC, Pratilas CA, Largaespada DA, Wood DK, Hirbe AC. Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology. Neuro Oncol. 2023:noad097. Epub 20230529. doi: 10.1093/neuonc/noad097. PubMed PMID: 37246765.

De Souza DC, Hebert N, Esrick EB, Ciuculescu MF, Archer NM, Armant M, Audureau É, Brendel C, Di Caprio G, Galactéros F, Liu D, McCabe A, Morris E, Schonbrun E, Williams D, Wood DK, Williams DA, Bartolucci P, Higgins JM. Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling. Nature Communications. 2023;14(1):5850. doi: 10.1038/s41467-023-40923-5.

Beckman JD, DaSilva A, Aronovich E, Nguyen A, Nguyen J, Hargis G, Reynolds D, Vercellotti GM, Betts B, Wood DK. JAK-STAT inhibition reduces endothelial prothrombotic activation and leukocyte–endothelial proadhesive interactions. Journal of Thrombosis and Haemostasis. 2023;21(5):1366-80.

2022

Wu X, Tang T, Wei Y, Cummins KA, Wood DK, Pang HB. Extracellular Vesicles Mediate the Intercellular Exchange of Nanoparticles. Adv Sci (Weinh). 2022;9(7):e2102441. Epub 20220117. doi: 10.1002/advs.202102441. PubMed PMID: 35243822; PMCID: PMC8895114.

Vunnam N, Hansen S, Williams DC, Been MO, Lo CH, Pandey AK, Paulson CN, Rohde JA, Thomas DD, Sachs JN, Wood DK. Fluorescence Lifetime Measurement of Prefibrillar Sickle Hemoglobin Oligomers as a Platform for Drug Discovery in Sickle Cell Disease. Biomacromolecules. 2022;23(9):3822-30. Epub 20220809. doi: 10.1021/acs.biomac.2c00671. PubMed PMID: 35944154; PMCID: PMC9472799.

Szafraniec HM, Valdez JM, Iffrig E, Lam WA, Higgins JM, Pearce P, Wood DK. Feature tracking microfluidic analysis reveals differential roles of viscosity and friction in sickle cell blood. Lab Chip. 2022;22(8):1565-75. Epub 20220412. doi: 10.1039/d1lc01133b. PubMed PMID: 35315465; PMCID: PMC9004467.

Ray A, Callaway MK, Rodriguez-Merced NJ, Crampton AL, Carlson M, Emme KB, Ensminger EA, Kinne AA, Schrope JH, Rasmussen HR, Jiang H, DeNardo DG, Wood DK, Provenzano PP. Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma. JCI Insight. 2022;7(3). Epub 20220208. doi: 10.1172/jci.insight.150330. PubMed PMID: 34914633; PMCID: PMC8855836.

Perazzo A, Peng Z, Young YN, Feng Z, Wood DK, Higgins JM, Stone HA. The effect of rigid cells on blood viscosity: linking rheology and sickle cell anemia. Soft Matter. 2022;18(3):554-65. Epub 20220119. doi: 10.1039/d1sm01299a. PubMed PMID: 34931640; PMCID: PMC8925304.

Hansen S, Wood DK. Simultaneous quantification of blood rheology and oxygen saturation to evaluate affinity-modifying therapies in sickle cell disease. Lab Chip. 2022;22(21):4141-50. Epub 20221025. doi: 10.1039/d2lc00623e. PubMed PMID: 36134535; PMCID: PMC10165883.

Geisness AC, Azul M, Williams D, Szafraniec H, De Souza DC, Higgins JM, Wood DK. Ionophore-mediated swelling of erythrocytes as a therapeutic mechanism in sickle cell disease. Haematologica. 2022;107(6):1438-47. Epub 20220601. doi: 10.3324/haematol.2021.278666. PubMed PMID: 34706495; PMCID: PMC9152977.

Azul M, Vital EF, Lam WA, Wood DK, Beckman JD. Microfluidic methods to advance mechanistic understanding and translational research in sickle cell disease. Transl Res. 2022;246:1-14. Epub 20220327. doi: 10.1016/j.trsl.2022.03.010. PubMed PMID: 35354090; PMCID: PMC9218997.

2021

Kramer AC, Astuti Y, Elfstrum A, Lehrke MJ, Tolar J, Blazar BR, Blake AL, Taisto ME, Furcich JW, Nolan EE, Durose WW, Webber BR, Geisness A, Wood DK, Lund TC. An irradiated marrow niche reveals a small noncollagenous protein mediator of homing, dermatopontin. Blood Adv. 2021;5(18):3609-22. doi: 10.1182/bloodadvances.2021004475. PubMed PMID: 34448828; PMCID: PMC8945574.

Demers M, Sturtevant S, Guertin KR, Gupta D, Desai K, Vieira BF, Li W, Hicks A, Ismail A, Goncalves BP, Di Caprio G, Schonbrun E, Hansen S, Musayev FN, Safo MK, Wood DK, Higgins JM, Light DR. MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease. Blood Adv. 2021;5(5):1388-402. doi: 10.1182/bloodadvances.2020003670. PubMed PMID: 33661300; PMCID: PMC7948285.

Cummins KA, Bitterman PB, Tschumperlin DJ, Wood DK. A scalable 3D tissue culture pipeline to enable functional therapeutic screening for pulmonary fibrosis. APL Bioeng. 2021;5(4):046102. Epub 20211116. doi: 10.1063/5.0054967. PubMed PMID: 34805716; PMCID: PMC8598262.

Choi KM, Haak AJ, Diaz Espinosa AM, Cummins KA, Link PA, Aravamudhan A, Wood DK, Tschumperlin DJ. GPCR-mediated YAP/TAZ inactivation in fibroblasts via EPAC1/2, RAP2C, and MAP4K7. J Cell Physiol. 2021;236(11):7759-74. Epub 20210528. doi: 10.1002/jcp.30459. PubMed PMID: 34046891; PMCID: PMC8530868.

2020

Smeester BA, Slipek NJ, Pomeroy EJ, Bomberger HE, Shamsan GA, Peterson JJ, Crosby MR, Draper GM, Becklin KL, Rahrmann EP, McCarthy JB, Odde DJ, Wood DK, Largaespada DA, Moriarity BS. SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis. Oncogene. 2020;39(5):1049-62. Epub 20191003. doi: 10.1038/s41388-019-1041-x. PubMed PMID: 31582836.

Kukla DA, Crampton AL, Wood DK, Khetani SR. Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in Three-Dimensional Models. Gene Expr. 2020;20(1):1-18. Epub 20200414. doi: 10.3727/105221620X15868728381608. PubMed PMID: 32290899; PMCID: PMC7284102.

Hansen S, Wood DK, Higgins JM. 5-(Hydroxymethyl)furfural restores low-oxygen rheology of sickle trait blood in vitro. Br J Haematol. 2020;188(6):985-93. Epub 20191230. doi: 10.1111/bjh.16251. PubMed PMID: 31889311; PMCID: PMC7150585.

Bazzi MS, Valdez JM, Barocas VH, Wood DK. An Experimental-Computational Approach to Quantify Blood Rheology in Sickle Cell Disease. Biophys J. 2020;119(11):2307-15. Epub 2020/10/24. doi: 10.1016/j.bpj.2020.10.011. PubMed PMID: 33096079; PMCID: PMC7732763.

2019

Di Caprio G, Schonbrun E, Goncalves BP, Valdez JM, Wood DK, Higgins JM. High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension. Proc Natl Acad Sci U S A. 2019;116(50):25236-42. Epub 20191125. doi: 10.1073/pnas.1914056116. PubMed PMID: 31767751; PMCID: PMC6911208.

Cummins KA, Crampton AL, Wood DK. A High-Throughput Workflow to Study Remodeling of Extracellular Matrix-Based Microtissues. Tissue Eng Part C Methods. 2019;25(1):25-36. Epub 2018/11/16. doi: 10.1089/ten.TEC.2018.0290. PubMed PMID: 30430922.

Castle BT, Odde DJ, Wood DK. Rapid and inefficient kinetics of sickle hemoglobin fiber growth. Sci Adv. 2019;5(3):eaau1086. Epub 2019/03/21. doi: 10.1126/sciadv.aau1086. PubMed PMID: 30891490; PMCID: PMC6415962.

2018

Lu X, Chaudhury A, Higgins JM, Wood DK. Oxygen-dependent flow of sickle trait blood as an in vitro therapeutic benchmark for sickle cell disease treatments. Am J Hematol. 2018;93(10):1227-35. Epub 20180821. doi: 10.1002/ajh.25227. PubMed PMID: 30033564; PMCID: PMC6604607.

Doak GR, Schwertfeger KL, Wood DK. Distant Relations: Macrophage Functions in the Metastatic Niche. Trends Cancer. 2018;4(6):445-59. Epub 20180503. doi: 10.1016/j.trecan.2018.03.011. PubMed PMID: 29860988; PMCID: PMC5990045.

Crampton AL, Cummins KA, Wood DK. A high-throughput microtissue platform to probe endothelial function in vitro. Integr Biol (Camb). 2018;10(9):555-65. doi: 10.1039/c8ib00111a. PubMed PMID: 30140833; PMCID: PMC6558661.

Brett ME, Bomberger HE, Doak GR, Price MA, McCarthy JB, Wood DK. In vitro elucidation of the role of pericellular matrix in metastatic extravasation and invasion of breast carcinoma cells. Integr Biol (Camb). 2018;10(4):242-52. Epub 2018/04/07. doi: 10.1039/c7ib00173h. PubMed PMID: 29623978.

2017

Lu X, Galarneau MM, Higgins JM, Wood DK. A microfluidic platform to study the effects of vascular architecture and oxygen gradients on sickle blood flow. Microcirculation. 2017;24(5). doi: 10.1111/micc.12357. PubMed PMID: 28129479; PMCID: PMC5505799.

Carden MA, Fay ME, Lu X, Mannino RG, Sakurai Y, Ciciliano JC, Hansen CE, Chonat S, Joiner CH, Wood DK, Lam WA. Extracellular fluid tonicity impacts sickle red blood cell deformability and adhesion. Blood. 2017;130(24):2654-63. Epub 2017/10/06. doi: 10.1182/blood-2017-04-780635. PubMed PMID: 28978568; PMCID: PMC5731085.

2016

Turley EA, Wood DK, McCarthy JB. Carcinoma Cell Hyaluronan as a "Portable" Cancerized Prometastatic Microenvironment. Cancer Res. 2016;76(9):2507-12. Epub 2016/05/20. doi: 10.1158/0008-5472.CAN-15-3114. PubMed PMID: 27197262; PMCID: PMC4874571.

Nam KH, Kim P, Wood DK, Kwon S, Provenzano PP, Kim DH. Multiscale Cues Drive Collective Cell Migration. Sci Rep. 2016;6:29749. Epub 20160727. doi: 10.1038/srep29749. PubMed PMID: 27460294; PMCID: PMC4962098.

Lu X, Wood DK, Higgins JM. Deoxygenation Reduces Sickle Cell Blood Flow at Arterial Oxygen Tension. Biophys J. 2016;110(12):2751-8. doi: 10.1016/j.bpj.2016.04.050. PubMed PMID: 27332133; PMCID: PMC4919586.

Brett ME, Wood DK. Microsystems Models of Pathophysiology. In: Love JC, editor. Micro‐ and Nanosystems for Biotechnology2016. p. 203-44.

Brett ME, Crampton AL, Wood DK. Rapid generation of collagen-based microtissues to study cell-matrix interactions. Technology. 2016;4(2):80-7. doi: 10.1142/S2339547816400094. PubMed PMID: WOS:000384443400002.